Hi Ihr's,
da hier ja nicht gerade wenige Aussieleute vertreten sind packe ich das hier einfach mal herein, - ich hoffe, ich kriege keine Schelte :shocked: .
Es ist der Bericht über den neuesten Stand der Kataraktstudie.
In simplen Worten:
Man hat im Laufe der Studie einige wenige Aussies gefunden, die ein mutiertes Gen tragen. Hunde, die diese Mutation zeigen, erkranken 11mal häufiger an "bilateral posterior polar cataracts" als andere (wie sich im Laufe der Studie zeigte).
Auch ist man der Meinung, dass diese Mutation sich dominant verhält. Will heißen, dass schon eine Kopie der Mutation reicht, um das Risiko, an erblichem Katarakt zu erkranken 11mal zu erhöhen.
Heißt auch, dass nicht unbedingt BEIDE Eltern von an eben dieser Form von Katarkt erkrankten Welpen dafür verantwortlich sein müssen, - es könnte sein, dass ein Elternteil reicht.
Hat ein solches Elternteil mit einem mutiertem Gen Nachwuchs, so ist rein rechnerisch 50 % davon ebenfalls mit dem höheren Risiko behaftet.
Gleichzeitig schreibt man, dass es möglich ist, dass es noch andere, bisher nicht entdeckte Mutationen geben kann, die das Kataraktrisiko erhöhen.
So, jetzt seit ihr hoffentlich alle schlauer *gg*
Ich bitte um Korrektur, wenn das in der Sache falsch übersetzt sein sollte, - ich bin nicht der Englischcrack, ist mein Versuch, das simpel rüberzubringen für die, die noch schlechter in Englisch sind :lol:
So, hier jetzt das Original (mit Erlaubnis zur Weiterverbreitung):
Below is the latest update ASHGI has received from the Animal Health Trust
in regard to their Australian Shepherd cataract research. The planned DNA
screening test is not yet commercially available, but we hope that it will
be later this year.
C.A. Sharp
Pres. ASHGI
Australian Shepherd Health & Genetics Institute, Inc.
All Aussies All Genes All the Time
www.ashgi.org
Genetic Mutation Associated With Hereditary Cataract In The
Australian Shepherd
Background
During 2006 researchers at the Animal Health Trust, UK identified a genetic
mutation in a small number of Australian Shepherds affected with Hereditary
Cataract (HC). To further investigate the relationship between the mutation
and HC in the breed the AHT, in collaboration with researchers at the
University of Helsinki, Finland, recruited a large number of additional
Australian Shepherd samples from the UK, Europe and USA. All the samples
were genotyped for the mutation and the results were analysed along with
each dog's cataract status.
The results show the mutation is a risk factor for the development of
cataract in the Australian Shepherd. There are currently no reports in the
scientific literature describing the clinical aspects of hereditary
cataracts in the Australian Shepherd but anecdotal evidence indicates
bilateral posterior polar cataracts are the most prevalent form. Our study
implies that the likelihood of developing bilateral posterior cataracts is
approximately 11 times higher for Australian Shepherds that carry the
mutation (either one or two copies) than it is for dogs that don't carry the
mutation. The mutation appears to be dominant, which means that dogs only
need to inherit a single copy of the mutation to be at increased risk of
developing cataracts. This also means that dogs/bitches that have produced
offspring with cataracts are not necessarily carriers of the mutation as the
affected offspring may have inherited a single copy of the mutation from
their other parent.
What Test Results Will Mean
If your dog carries one or two copies of the mutation it has an increased
chance of developing bilateral posterior cataracts. We currently estimate
it is about 11 times more likely to develop this type of cataract than a dog
that doesn't carry the mutation. Our estimate of the increased likelihood
may change slightly as we analyse more data but is unlikely to change
significantly. If your dog does not carry the mutation it has a lower
chance of developing cataracts, during its lifetime. It is possible that
additional mutations exist in the Australian Shepherd population that are
also risk factors for the development of cataracts; our DNA test does not
currently detect these mutations.
If your dog carries a single copy of the mutation it will pass the mutation
(and the increased risk of developing cataracts) onto to approximately 50%
of its offspring. If it carries two copies of the mutation it will pass the
mutation onto all of its offspring.
da hier ja nicht gerade wenige Aussieleute vertreten sind packe ich das hier einfach mal herein, - ich hoffe, ich kriege keine Schelte :shocked: .
Es ist der Bericht über den neuesten Stand der Kataraktstudie.
In simplen Worten:
Man hat im Laufe der Studie einige wenige Aussies gefunden, die ein mutiertes Gen tragen. Hunde, die diese Mutation zeigen, erkranken 11mal häufiger an "bilateral posterior polar cataracts" als andere (wie sich im Laufe der Studie zeigte).
Auch ist man der Meinung, dass diese Mutation sich dominant verhält. Will heißen, dass schon eine Kopie der Mutation reicht, um das Risiko, an erblichem Katarakt zu erkranken 11mal zu erhöhen.
Heißt auch, dass nicht unbedingt BEIDE Eltern von an eben dieser Form von Katarkt erkrankten Welpen dafür verantwortlich sein müssen, - es könnte sein, dass ein Elternteil reicht.
Hat ein solches Elternteil mit einem mutiertem Gen Nachwuchs, so ist rein rechnerisch 50 % davon ebenfalls mit dem höheren Risiko behaftet.
Gleichzeitig schreibt man, dass es möglich ist, dass es noch andere, bisher nicht entdeckte Mutationen geben kann, die das Kataraktrisiko erhöhen.
So, jetzt seit ihr hoffentlich alle schlauer *gg*
Ich bitte um Korrektur, wenn das in der Sache falsch übersetzt sein sollte, - ich bin nicht der Englischcrack, ist mein Versuch, das simpel rüberzubringen für die, die noch schlechter in Englisch sind :lol:
So, hier jetzt das Original (mit Erlaubnis zur Weiterverbreitung):
Below is the latest update ASHGI has received from the Animal Health Trust
in regard to their Australian Shepherd cataract research. The planned DNA
screening test is not yet commercially available, but we hope that it will
be later this year.
C.A. Sharp
Pres. ASHGI
Australian Shepherd Health & Genetics Institute, Inc.
All Aussies All Genes All the Time
www.ashgi.org
Genetic Mutation Associated With Hereditary Cataract In The
Australian Shepherd
Background
During 2006 researchers at the Animal Health Trust, UK identified a genetic
mutation in a small number of Australian Shepherds affected with Hereditary
Cataract (HC). To further investigate the relationship between the mutation
and HC in the breed the AHT, in collaboration with researchers at the
University of Helsinki, Finland, recruited a large number of additional
Australian Shepherd samples from the UK, Europe and USA. All the samples
were genotyped for the mutation and the results were analysed along with
each dog's cataract status.
The results show the mutation is a risk factor for the development of
cataract in the Australian Shepherd. There are currently no reports in the
scientific literature describing the clinical aspects of hereditary
cataracts in the Australian Shepherd but anecdotal evidence indicates
bilateral posterior polar cataracts are the most prevalent form. Our study
implies that the likelihood of developing bilateral posterior cataracts is
approximately 11 times higher for Australian Shepherds that carry the
mutation (either one or two copies) than it is for dogs that don't carry the
mutation. The mutation appears to be dominant, which means that dogs only
need to inherit a single copy of the mutation to be at increased risk of
developing cataracts. This also means that dogs/bitches that have produced
offspring with cataracts are not necessarily carriers of the mutation as the
affected offspring may have inherited a single copy of the mutation from
their other parent.
What Test Results Will Mean
If your dog carries one or two copies of the mutation it has an increased
chance of developing bilateral posterior cataracts. We currently estimate
it is about 11 times more likely to develop this type of cataract than a dog
that doesn't carry the mutation. Our estimate of the increased likelihood
may change slightly as we analyse more data but is unlikely to change
significantly. If your dog does not carry the mutation it has a lower
chance of developing cataracts, during its lifetime. It is possible that
additional mutations exist in the Australian Shepherd population that are
also risk factors for the development of cataracts; our DNA test does not
currently detect these mutations.
If your dog carries a single copy of the mutation it will pass the mutation
(and the increased risk of developing cataracts) onto to approximately 50%
of its offspring. If it carries two copies of the mutation it will pass the
mutation onto all of its offspring.
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